Peyronie’s Disease and the P-Shot: Can PRP Fix a Curved Penis?

Written by Dr Shirin Lakhani MBBS MRCGP DRCOG — GMC No. 4634863 | CQC-Registered Practitioner | Medical Director, Elite Aesthetics, Greenhithe, Dartford, Kent

Peyronie’s disease is far more common than most men realise — and far more treatable than many believe. Studies estimate it affects between 3% and 9% of men, with prevalence rising sharply after the age of 40 and peaking in men in their 50s and 60s. Yet the shame and embarrassment surrounding a curved or bent penis means the vast majority of affected men never seek help, suffering in silence through painful erections, reduced sexual confidence, and — in many cases — worsening erectile dysfunction.

At Elite Aesthetics in Greenhithe, Dartford, Kent — 22 minutes from London — we see men with Peyronie’s disease regularly. And over the past several years, one treatment has emerged as one of the most promising non-surgical options available: the P-Shot, or Priapus Shot, which uses platelet-rich plasma (PRP) derived from the patient’s own blood to stimulate tissue repair and reduce the fibrous plaques that cause penile curvature.

In this guide, Dr Shirin Lakhani explains what Peyronie’s disease actually is, how the P-Shot works, what the research says, and what realistic results look like — so you can make an informed decision about whether this treatment is right for you.

What Is Peyronie’s Disease?

Peyronie’s disease is a connective tissue disorder in which fibrous scar tissue — known as a plaque — develops inside the penis, typically within the tunica albuginea, the tough sheath that surrounds the erectile chambers. This plaque cannot stretch the way healthy tissue can, which causes the penis to curve, bend, or become indented during an erection.

The condition often develops after minor trauma or repeated microinjuries to the penis — sometimes so minor the man doesn’t recall a specific incident. In other cases it appears to develop spontaneously, particularly in men with a genetic predisposition or connective tissue disorders such as Dupuytren’s contracture.

Peyronie’s disease typically progresses in two phases:

• Active phase (6–18 months): The plaque is forming, curvature may be worsening, and erections are often painful. This is the most distressing stage for most men.
• Chronic/stable phase: The plaque has calcified and the curvature has stabilised. Pain usually subsides, though curvature and erectile dysfunction often persist.

In addition to physical symptoms, Peyronie’s disease has a significant psychological impact. Research consistently shows high rates of depression, relationship strain, and reduced quality of life among affected men — yet uptake of treatment remains low because men are reluctant to discuss it with a doctor.

How the P-Shot Works for Peyronie’s Disease

The P-Shot — formally known as the Priapus Shot — involves injecting concentrated platelet-rich plasma (PRP) directly into the penile tissue, including the area of the plaque. PRP is produced by taking a small sample of the patient’s own blood, spinning it in a centrifuge to concentrate the platelets, and then injecting this growth-factor-rich solution into the target area.

Platelets are best known for their role in blood clotting, but they also release a range of powerful growth factors — including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β) — that stimulate tissue remodelling, collagen production, and new blood vessel formation.

In the context of Peyronie’s disease, the proposed mechanism is that PRP:

• Promotes the breakdown and remodelling of fibrous plaque tissue
• Reduces local inflammation within the tunica albuginea
• Stimulates healthy collagen production to replace the rigid scar tissue
• Improves blood flow to the penile tissue, supporting erectile function

Because the treatment uses the patient’s own blood, there is no risk of allergic reaction or rejection — making it one of the safest minimally invasive options available for men with Peyronie’s disease.

What Does the P-Shot Treatment Involve at Elite Aesthetics?

At Elite Aesthetics in Greenhithe, Dartford, Kent, all P-Shot treatments are performed by Dr Shirin Lakhani (GMC No. 4634863), a fully qualified GP and aesthetic physician with extensive experience in PRP-based treatments. Every procedure takes place in our CQC-registered clinic, ensuring the highest standards of clinical safety and patient care.

Here is what to expect at your appointment:

1. Consultation: Dr Shirin will review your medical history, assess the degree of curvature, discuss your symptoms, and confirm you are a suitable candidate for the P-Shot.
2. Blood draw: A small amount of blood is taken from your arm — typically around 30–60ml — using standard venepuncture.
3. PRP preparation: The blood is placed in a centrifuge and spun for around 10 minutes to separate and concentrate the platelets.
4. Topical anaesthetic: A numbing cream is applied to the penis and left for 20–30 minutes to minimise any discomfort during the injection.
5. Injection: The PRP is injected precisely into the penile tissue, including directly into the plaque. Most patients describe this as a mild pressure or warm sensation rather than significant pain.
6. Aftercare: You will receive aftercare guidance including advice on when to resume sexual activity and how to support the healing process.

The full appointment takes approximately 60–90 minutes. Most men find it straightforward and return to normal daily activities the same day.

P-Shot vs Other Peyronie’s Disease Treatments: How Does It Compare?

Peyronie’s disease has several treatment options, ranging from conservative management to surgery. Here is how the P-Shot compares to the most common alternatives available in the UK:

For most men with mild to moderate Peyronie’s disease who want to avoid the risks and downtime of surgery, the P-Shot — often in combination with low-intensity shockwave therapy — represents a compelling first-line option.

What Does the Research Say?

The evidence base for PRP in Peyronie’s disease is growing. A 2025 single-centre retrospective cohort study published in Medicina (MDPI) assessed men with chronic Peyronie’s disease treated with three weekly intralesional PRP injections. Researchers reported meaningful reductions in curvature and improvements in erectile function, with no significant adverse effects recorded.

An ongoing clinical trial registered with ClinicalTrials.gov (NCT07010900) is currently comparing platelet-rich plasma injections combined with penile traction against traction alone — further evidence that the research community is taking PRP for Peyronie’s disease seriously as a treatment option.

It is important to note that the European Association of Urology currently classifies PRP for Peyronie’s disease as experimental, recommending its use within the context of clinical protocols. At Elite Aesthetics in Greenhithe, Dartford, Kent — 22 minutes from London — Dr Shirin Lakhani discusses this evidence base in full during every consultation, ensuring patients can make a genuinely informed decision.

Who Is a Good Candidate for the P-Shot for Peyronie’s Disease?

The P-Shot is not suitable for every man with Peyronie’s disease. During your consultation with Dr Shirin, the following criteria will be assessed to determine whether you are a good candidate:

• ✅ You have been diagnosed with Peyronie’s disease (or have symptoms consistent with it)
• ✅ Your curvature is mild to moderate (typically less than 60 degrees)
• ✅ You are in the stable or chronic phase (curvature has not worsened for at least 3–6 months)
• ✅ You are in good general health and have no active infection
• ✅ You are not taking blood-thinning medications that cannot be paused
• ✅ You have realistic expectations about the degree of improvement achievable
• ❌ Not suitable if: you are in the active/painful phase and curvature is still worsening
• ❌ Not suitable if: your curvature is severe (>60°) — surgical evaluation may be more appropriate

Many men who visit us at Elite Aesthetics are initially unsure whether the P-Shot is right for them. That is exactly what the free 15-minute initial chat is for — to help you understand your options without any pressure to commit to treatment.

What Results Can You Expect?

Results from the P-Shot for Peyronie’s disease vary depending on the degree of curvature, how long the condition has been present, and whether it is combined with other treatments such as shockwave therapy. In general, patients can expect:

• Weeks 1–4: Little visible change as the growth factors begin working at a cellular level. Some men notice a reduction in pain if the condition was causing discomfort.
• Months 1–3: Gradual softening of the plaque and early reduction in curvature become noticeable. Erectile quality may begin to improve.
• Months 3–6: Peak results for most patients. Studies report average reductions in curvature of 30–40% with PRP treatment, along with improvements in erectile function scores.
• Beyond 6 months: Results are typically durable for 12–18 months. A second session may be recommended to maintain or build upon the initial response.

It is important to be honest: the P-Shot is unlikely to completely straighten a significantly curved penis on its own. Its greatest value is in reducing curvature to a degree that restores comfortable, confident sexual function — and in improving erectile quality simultaneously, something that surgery does not address.