P-Shot for Peyronie’s Disease: A Non-Surgical Regenerative Treatment Guided by Clinical Expertise

Written by Dr Shirin Lakhani, Elite Aesthetics

Introduction: Reframing Peyronie’s Disease With Modern, Regenerative Care

Peyronie’s disease is a condition that affects far more than physical anatomy. Men living with penile curvature often experience pain, erectile difficulties, anxiety, and a profound impact on confidence and intimacy. Many delay seeking help due to embarrassment or because they are told that little can be done without surgery.

In reality, early and appropriately targeted treatment can make a meaningful difference. Advances in regenerative medicine now allow us to move beyond a purely surgical mindset and towards treatments that support healing, function, and long-term tissue health.

One such approach is the P-Shot for Peyronie’s disease, a non-surgical treatment using platelet-rich plasma combined with precise mechanical breakdown of plaque using a needle, performed by an experienced clinician.

This guide explains how the treatment works, who it is suitable for, what outcomes are realistic, and why clinical expertise matters profoundly when treating Peyronie’s disease.

Understanding Peyronie’s Disease in Clinical Practice

Peyronie’s disease is caused by the formation of fibrous scar tissue within the tunica albuginea, the tough connective layer that surrounds the erectile chambers of the penis.

This scar tissue, known as plaque, interferes with the normal elasticity of the penis during erection.

Common features include:

• Curvature or bending of the penis
• Pain, especially during erections
• Erectile dysfunction
• Penile shortening or narrowing
• Emotional distress and avoidance of intimacy

From a clinical perspective, Peyronie’s disease is best understood in two phases.

The active phase is characterised by inflammation, pain, and changing curvature. This is often the most responsive time for non-surgical intervention.

The stable phase occurs once pain settles and curvature stops progressing. Treatment is still possible, but goals may differ.

Understanding the stage of disease is essential for tailoring treatment and setting positive, realistic expectations.

What Is the P-Shot for Peyronie’s Disease?

The P-Shot, also known as the Priapus Shot, uses platelet-rich plasma (PRP) derived from your own blood.

PRP contains a concentrated level of growth factors, healing proteins, and cellular signalling molecules. These components play a role in tissue repair, vascular health, and cellular regeneration.

When used for Peyronie’s disease, the P-Shot is not a cosmetic or enhancement procedure. It is a medically guided regenerative treatment designed to support healing and improve function in compromised tissue.

A Key Clinical Element: Mechanical Plaque Breakdown

At Elite Aesthetics, the P-Shot for Peyronie’s disease includes an important additional step.

During treatment, the Peyronie’s plaque is carefully and deliberately broken down using a fine needle before and during PRP injection.

This approach:

• Mechanically disrupts dense fibrotic tissue
• Helps soften the plaque
• Allows PRP to penetrate the affected area more effectively
• Stimulates a controlled healing response

By combining targeted plaque needling with regenerative PRP, we aim to enhance tissue response and optimise functional outcomes.

How PRP and Plaque Needling Work Together

Peyronie’s disease involves abnormal collagen behaviour, restricted elasticity, and compromised blood flow. The combined approach addresses these factors together.

Supporting healthier collagen remodelling

Mechanical disruption alters plaque structure, while PRP supports rebuilding tissue in a more organised and functional way over time.

Supporting erectile function

PRP promotes microvascular health, which can significantly benefit men experiencing erectile dysfunction alongside Peyronie’s disease.

Reducing pain and sensitivity

Many men experience reduced pain following treatment, particularly when intervention occurs earlier.

Improving functional curvature

Although complete straightening cannot be promised, many patients report improved function, reduced restriction, and greater comfort during erections.

What Outcomes Can Patients Expect?

The P-Shot for Peyronie’s disease is best viewed as a progressive, regenerative treatment.

Men commonly pursue treatment to:

• Reduce pain
• Improve erectile quality
• Soften plaque
• Improve functional curvature
• Preserve penile length
• Restore confidence

When treatment is appropriately selected and expertly delivered, outcomes are often very encouraging. Improvements tend to occur gradually over weeks to months as tissue remodelling takes place.

Success is measured not only by degrees of curvature, but by comfort, function, and quality of life.

Who Is a Suitable Candidate?

You may be well suited to this treatment if you:

• Have mild to moderate Peyronie’s disease
• Are in the active or stable phase
• Experience pain or erectile dysfunction
• Prefer a non-surgical approach
• Want proactive, medically guided care

A thorough consultation is essential to assess plaque location, disease stage, erectile function, and treatment goals.

The P-Shot Procedure: What to Expect

The procedure is performed in clinic and typically lasts 30 to 45 minutes.

It involves:

• A small blood sample
• Preparation of platelet-rich plasma
• Local anaesthetic to ensure comfort
• Targeted needling to break down plaque
• PRP injections into carefully selected areas

Most patients find the procedure very manageable.

Recovery and Aftercare

Downtime is minimal. You may notice mild swelling, temporary tenderness, or occasional bruising.

Most men return to normal daily activities the same day. Individual guidance is provided regarding sexual activity and aftercare.

How Many Treatments Are Required?

Treatment plans are personalised. Some men experience benefit after a single session, while others achieve optimal results with a planned course of treatments. This depends on plaque severity, disease duration, erectile function, and individual response.

Progress is reviewed carefully before recommending further treatment.

Safety Profile and Clinical Considerations

PRP is derived from your own blood, making it a very safe treatment with a low risk profile.

When combined with controlled plaque needling and expert technique, risks remain low and outcomes are generally favourable.

As with all regenerative treatments, results vary, but careful patient selection significantly improves success.

Why Experience Matters in Peyronie’s Disease Treatment

Peyronie’s disease does not benefit from a one-size-fits-all approach.

Effective treatment requires:

• Detailed anatomical understanding
• Experience with regenerative medicine
• Confidence in plaque assessment and needling
• Clear communication and expectation management

Clinical expertise directly influences outcomes.

About Dr Shirin Lakhani

Dr Shirin Lakhani is one of the UK’s most respected doctors in regenerative and intimate health medicine.

She is a qualified medical doctor with extensive clinical experience and an international trainer in PRP, P-Shot, and O-Shot treatments. She is widely recognised for her work in sexual and intimate health and regularly features in national media discussing complex and sensitive health conditions.

Dr Lakhani has treated thousands of patients with intimate health concerns and is known for her calm, evidence-based, patient-centred approach.

Her experience with PRP extends beyond aesthetics into functional and regenerative medicine, where precision, safety, and anatomy are critical.

For men with Peyronie’s disease, this means:

• Accurate plaque assessment
• Careful, controlled plaque needling
• Thoughtful use of PRP
• Honest outcome discussions
• Personalised treatment planning

Patients consistently report feeling listened to, reassured, and supported.

Frequently Asked Questions

Does breaking down the plaque improve results?

Mechanical plaque disruption can soften fibrotic tissue and improve PRP penetration, which may enhance functional outcomes.

Can the P-Shot cure Peyronie’s disease?

Peyronie’s disease is a chronic condition. The P-Shot aims to improve symptoms and function rather than offer a cure.

Is the procedure painful?

Local anaesthetic is used and most patients tolerate the procedure very well.

Is this suitable if I want to avoid surgery?

Yes. Many men choose this non-surgical option before considering invasive treatments.

How soon will I notice improvement?

Changes typically develop gradually over several weeks as healing and remodelling occur.

When to Seek Specialist Advice

Early assessment often leads to better outcomes and more treatment options.

At Elite Aesthetics, we offer discreet, medically led care for men’s intimate health, including:

• P-Shot treatment
• Erectile dysfunction treatment

A Calm, Confidential Next Step

The goal is always to restore comfort, function, and confidence through evidence-based, patient-centred care.